Cell Surface Metabolic Glycoengineering Service (MGE)

Significance of Cell Surface MGE in Disease Research

The cell surface MGE can explore and modify the structure of cell surface glycoconjugates to enable precise modulation of cell interactions. By utilizing MGE, researchers can alter the structure of cell-surface glycoconjugates and thus study their functions and mechanisms in cell biology and disease development. Many diseases are associated with aberrant cell surface MGE can be used to simulate cell surface glycan modification in disease states, thereby providing insight into the mechanisms of disease development. Performing specific glycan modifications in disease-related cell models, can reveal the effects of abnormal cellular glycosylation on disease progression and open up new ideas for disease research.

Fig.1 Overview of MGE. (Agatemor, et al., 2019)

Cell Surface MGE Service at CD BioGlyco

With our advanced technologies and expertise, CD BioGlyco offers customized Cell Surface Metabolic Oligosaccharide Engineering Services (MOE), Cell Surface Chemoenzymatic Glycoengineering Services (CGE), and cell surface MGE services. Our specialized cell surface MGE services include but are not limited to the following:

Applications

• With cell surface MGE, specific glycosylation modifications can be introduced on cells expressing proteins to modulate the pharmacological properties of the proteins.
• Cell recognition and interactions can be modulated through glycosylation modifications on the cell surface.
• By using cell surface MGE, specific glycosylation modifications can be introduced on the cell surface to enable the recognition and detection of specific molecules.

Advantages of Us

• Cell surface MGE technologies are highly controllable, allowing us to target design and manipulation to precisely modulate cell surface glycosylation modifications according to your specific research needs.
• Cell surface MGE techniques utilize different combinations of substrates and enzymes to introduce a variety of mono- or polysaccharide structures and consequently offer great versatility and flexibility.
• We have a variety of resources and facilities that provide strong support for research and applications in cell surface MGE.

By utilizing a comprehensive Glycoengineering Platform, CD BioGlyco provides first-class and thoughtful cell surface MGE services by customizing detailed and rigorous experimental processes based on clients' scientific needs. Please feel free to contact us directly if you are interested in our cell surface MGE services.